{"id":6361,"date":"2023-10-11T20:13:23","date_gmt":"2023-10-11T20:13:23","guid":{"rendered":"https:\/\/dailyai.com\/?p=6361"},"modified":"2023-10-11T20:21:52","modified_gmt":"2023-10-11T20:21:52","slug":"ai-models-helps-brain-surgeons-detect-and-analyze-tumor-types-on-the-fly","status":"publish","type":"post","link":"https:\/\/dailyai.com\/sv\/2023\/10\/ai-models-helps-brain-surgeons-detect-and-analyze-tumor-types-on-the-fly\/","title":{"rendered":"Ny AI-modell hj\u00e4lper hj\u00e4rnkirurger att analysera tum\u00f6rer i farten"},"content":{"rendered":"

Hj\u00e4rnkirurger brottas ofta med kritiska beslut under hela tum\u00f6rborttagningsprocessen.\u00a0<\/b><\/p>\n

Nu har holl\u00e4ndska forskare introducerat ett AI-verktyg f\u00f6r att underl\u00e4tta den intraoperativa beslutsprocessen och ge kirurgerna ultrasnabba insikter om tum\u00f6rtyper och subtyper.<\/p>\n

Enligt en nyligen publicerad <\/span>studie publicerad i Nature<\/span><\/a>AI:n unders\u00f6ker specifika segment av en tum\u00f6rs DNA och identifierar distinkta kemiska strukturer. <\/span><\/p>\n

Denna analys ger insikter om tum\u00f6rens typ och eventuellt dess subtyp. S\u00e5dan information i r\u00e4tt tid kan v\u00e4gleda kirurgerna i deras tillv\u00e4gag\u00e5ngss\u00e4tt vid det kirurgiska ingreppet.<\/span><\/p>\n

\"Det \u00e4r absolut n\u00f6dv\u00e4ndigt att tum\u00f6rens subtyp \u00e4r k\u00e4nd vid tidpunkten f\u00f6r operationen\", s\u00e4ger Jeroen de Ridder, docent vid UMC Utrecht. \"Det vi nu har gjort m\u00f6jligt \u00e4r att l\u00e5ta denna mycket finkorniga, robusta och detaljerade diagnos utf\u00f6ras redan under operationen.\"<\/span><\/p>\n

Deras system f\u00f6r djupinl\u00e4rning, Sturgeon, utsattes f\u00f6r rigor\u00f6sa tester. I vissa inledande tester avstod AI:n fr\u00e5n att st\u00e4lla diagnos p\u00e5 grund av tvetydiga data.<\/span><\/p>\n

Forskarna visade att modellen fungerar i realtid vid 25 operationer och uppn\u00e5dde en snabb diagnostisk behandlingstid p\u00e5 mindre \u00e4n 90 minuter, vilket \u00e4r mycket snabbare \u00e4n med traditionella metoder. 72% av diagnoserna var korrekta, men sju n\u00e5dde inte upp till den n\u00f6dv\u00e4ndiga konfidensgr\u00e4nsen.<\/p>\n

Medan den diagnostiska standardprocessen inneb\u00e4r en mikroskopisk unders\u00f6kning av prover fr\u00e5n hj\u00e4rntum\u00f6rer, ger omfattande genetisk sekvensering djupare insikter. Men som Dr Alan Cohen fr\u00e5n Johns Hopkins p\u00e5pekade: \"Vi m\u00e5ste p\u00e5b\u00f6rja behandlingen utan att veta vad vi behandlar.\"<\/span><\/p>\n

Dr de Ridder f\u00f6rklarade AI:ns kapacitet ytterligare: \"Den kan sj\u00e4lv r\u00e4kna ut vad den tittar p\u00e5 och g\u00f6ra en robust klassificering.\"<\/span><\/p>\n

\u00c4nd\u00e5 kvarst\u00e5r vissa utmaningar. Variabilitet inom tum\u00f6ren, provstorlek och vissa sv\u00e5rf\u00e5ngade tum\u00f6rer kan utg\u00f6ra sv\u00e5righeter. Marc Pag\u00e8s-Gallego, medf\u00f6rfattare till en av studierna, gav en bakgrund till hur de navigerade i dessa fr\u00e5gor.<\/span><\/p>\n

Dr Sebastian Brandner fr\u00e5n University College London kommenterade de praktiska aspekterna och konstaterade att \"sj\u00e4lva implementeringen \u00e4r mindre enkel \u00e4n vad som ofta antyds\".<\/span><\/p>\n

\u00c4ven om verktyget inneb\u00e4r ett betydande steg fram\u00e5t har det sina begr\u00e4nsningar.\u00a0<\/span><\/p>\n

A<\/span>Dr Cohen medgav: \"Vi har gjort vissa framsteg, men inte lika stora framsteg n\u00e4r det g\u00e4ller behandlingen som n\u00e4r det g\u00e4ller f\u00f6rst\u00e5elsen av tum\u00f6rernas molekyl\u00e4ra profil.\"<\/span><\/p>\n

Mer om studien<\/span><\/h2>\n

Det innovativa verktyget \"Sturgeon\" anv\u00e4nder djupinl\u00e4rning f\u00f6r att f\u00f6rb\u00e4ttra den intraoperativa klassificeringen av hj\u00e4rntum\u00f6rer, vilket bidrar till b\u00e4ttre kirurgiskt beslutsfattande.\u00a0<\/span><\/p>\n

Modellen \u00e4r utformad f\u00f6r att vara \"ultrasnabb\" n\u00e4r det g\u00e4ller att klassificera tum\u00f6rtyper och subtyper.<\/span><\/p>\n

    \n
  • Utmaningar:<\/b> Att klassificera tum\u00f6rer under operation \u00e4r sv\u00e5rt p\u00e5 grund av begr\u00e4nsad sekvenseringstid och os\u00e4ker datat\u00e4ckning.\u00a0<\/span><\/li>\n
  • Sturgeons l\u00f6sning:<\/b> Detta djupinl\u00e4rningssystem anv\u00e4nder data fr\u00e5n allm\u00e4nt tillg\u00e4ngliga metyleringsarray-data, som anv\u00e4nds f\u00f6r att profilera hj\u00e4rntum\u00f6rer. Sturgeon outsourcar intensiva ber\u00e4kningsuppgifter f\u00f6r att minimera ber\u00e4kningsresurserna under operationen.<\/span><\/li>\n
  • Prestanda:<\/b> Modellen har visat konsekventa resultat men tar ofta inte h\u00e4nsyn till variationen inom tum\u00f6ren. Den gav r\u00e4tt diagnos i 72% av de kirurgiska testerna.\u00a0<\/span><\/li>\n
  • Framtida utveckling:<\/b> I takt med att mer data samlas in kommer Sturgeons data att f\u00f6rb\u00e4ttras, \u00e4ven om restriktioner f\u00f6r datadelning p\u00e5 grund av integritetsh\u00e4nsyn g\u00f6r det sv\u00e5rt att l\u00e4ra sig mer mellan institutionerna.\u00a0<\/span><\/li>\n
  • Begr\u00e4nsningar:<\/b> En potentiell begr\u00e4nsning \u00e4r den v\u00e4vnadsm\u00e4ngd som kr\u00e4vs. Modellen kr\u00e4ver en provstorlek p\u00e5 cirka 5 x 5 x 5 mm f\u00f6r b\u00e4sta resultat, men tillr\u00e4ckligt med DNA har framg\u00e5ngsrikt extraherats fr\u00e5n mindre prover.<\/span><\/li>\n<\/ul>\n

    Med Sturgeon kan tum\u00f6rdiagnostiska resultat uppn\u00e5s inom 90 minuter, vilket \u00e4r i linje med kirurgiska tidsramar. Detta ger kirurgerna insikter i realtid, vilket g\u00f6r att de kan fatta b\u00e4ttre beslut under operationen.\u00a0<\/span><\/p>\n

    Sturgeons data \u00e4r visserligen anv\u00e4ndbara, men enligt studien b\u00f6r de helst anv\u00e4ndas tillsammans med en utbildad patologs bed\u00f6mning.\u00a0<\/span><\/p>\n

    Sturgeon s\u00e4llar sig till skaran av banbrytande medicinskt inriktade AI-modeller som skapats i \u00e5r, vilket illustrerar teknikens f\u00f6rm\u00e5ga att f\u00f6r\u00e4ndra v\u00e5rdresultaten.<\/p>","protected":false},"excerpt":{"rendered":"

    Hj\u00e4rnkirurger brottas ofta med kritiska beslut under hela tum\u00f6rborttagningsprocessen. Nu har holl\u00e4ndska forskare introducerat ett AI-verktyg f\u00f6r att underl\u00e4tta den intraoperativa beslutsprocessen och ge kirurgerna ultrasnabba insikter om tum\u00f6rtyper och subtyper. Enligt en studie som nyligen publicerades i Nature unders\u00f6ker AI specifika segment av tum\u00f6rens DNA och identifierar distinkta kemiska strukturer. Denna analys ger insikter om tum\u00f6rens typ och eventuellt dess subtyp. S\u00e5dan information i r\u00e4tt tid kan v\u00e4gleda kirurgerna i deras tillv\u00e4gag\u00e5ngss\u00e4tt vid den kirurgiska operationen. \"Det \u00e4r absolut n\u00f6dv\u00e4ndigt att tum\u00f6rens subtyp \u00e4r k\u00e4nd vid tidpunkten f\u00f6r operationen\", s\u00e4ger Jeroen de Ridder, en av<\/p>","protected":false},"author":2,"featured_media":6362,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[203,204,101],"class_list":["post-6361","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ethics","tag-biotech","tag-healthcare","tag-medtech"],"yoast_head":"\nNew AI model helps brain surgeons analyze tumors on the fly | DailyAI<\/title>\n<meta name=\"description\" content=\"Brain surgeons often grapple with critical decisions when addressing the boundaries of tumors.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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