{"id":2384,"date":"2023-07-07T20:16:06","date_gmt":"2023-07-07T20:16:06","guid":{"rendered":"https:\/\/dailyai.com\/?p=2384"},"modified":"2023-07-07T21:05:18","modified_gmt":"2023-07-07T21:05:18","slug":"ai-accelerates-discovery-of-anti-aging-drugs-in-new-study","status":"publish","type":"post","link":"https:\/\/dailyai.com\/sv\/2023\/07\/ai-accelerates-discovery-of-anti-aging-drugs-in-new-study\/","title":{"rendered":"AI p\u00e5skyndar uppt\u00e4ckten av l\u00e4kemedel mot \u00e5ldrande i ny studie"},"content":{"rendered":"

Ett internationellt team av forskare fr\u00e5n University of Edinburgh och det spanska forskningsr\u00e5det IBBTEC-CSIC anv\u00e4nde AI f\u00f6r att p\u00e5skynda uppt\u00e4ckten av l\u00e4kemedel mot \u00e5ldrande.\u00a0<\/b><\/p>\n

Deras <\/span>studie<\/span><\/a> identifierat 3 potentiella senolytiska l\u00e4kemedel som kan bromsa \u00e5ldrandet och f\u00f6rebygga \u00e5ldersrelaterade sjukdomar. Dessa l\u00e4kemedel fungerar genom att eliminera senescenta celler, ofta kallade \"zombieceller\". S\u00e5dana celler f\u00f6rblir metaboliskt aktiva men kan inte replikera sig.<\/span><\/p>\n

Att stoppa cellreplikationen fungerar som en f\u00f6rsvarsmekanism f\u00f6r att f\u00f6rhindra spridning av cellskador, men det \u00e4r inte helt okomplicerat.\u00a0<\/span><\/p>\n

Denna skydds\u00e5tg\u00e4rd \u00e4r fr\u00e4mst utformad f\u00f6r att f\u00f6rhindra spridning av celler som har drabbats av DNA-skador - till exempel celler som har skadats av exponering f\u00f6r solljus. Genom att stoppa replikationen av dessa skadade celler ser kroppen till att skadan inte sprids till fler celler.<\/span><\/p>\n

De celler som har slutat dela sig, s\u00e5 kallade senescenta celler, kan dock potentiellt orsaka skada. N\u00e4r de g\u00e5r in i senescensfasen b\u00f6rjar de fris\u00e4tta proteiner som \u00e4r k\u00e4nda f\u00f6r att orsaka inflammation.\u00a0<\/span><\/p>\n

Detta kan p\u00e5verka n\u00e4rliggande friska celler och potentiellt skapa en inflammatorisk milj\u00f6.\u00a0<\/span>Med tiden kan denna ansamling av inflammation bidra till olika h\u00e4lsokomplikationer.\u00a0<\/span><\/p>\n

Inflammation \u00e4r till exempel kopplat till m\u00e5nga sjukdomar, bland annat neurologiska och degenerativa sjukdomar, typ 2-diabetes, lungfibros, artros och cancer.\u00a0<\/span><\/p>\n

\u00c4ven om upph\u00f6randet av cellreplikationen \u00e4r avg\u00f6rande f\u00f6r att f\u00f6rhindra spridning av DNA-skador, kan det inflammatoriska svaret i samband med senescenta celler leda till andra h\u00e4lsoproblem om det inte hanteras p\u00e5 r\u00e4tt s\u00e4tt.<\/span><\/p>\n

Och det \u00e4r d\u00e4r senolytiska l\u00e4kemedel kan hj\u00e4lpa till.\u00a0<\/span><\/p>\n

AI:s roll<\/span><\/h2>\n

Tidigare forskning p\u00e5 laboratoriem\u00f6ss visade att senolytiska l\u00e4kemedel f\u00f6rb\u00e4ttrar detta inflammatoriska scenario genom att eliminera senescenta celler och skona de friska.\u00a0<\/span><\/p>\n

Det finns cirka 80 k\u00e4nda senolytika, men endast en kombination av tv\u00e5, dasatinib och quercetin, har testats p\u00e5 m\u00e4nniskor.\u00a0<\/span><\/p>\n

Uppt\u00e4ckten av nya l\u00e4kemedel \u00e4r exceptionellt kostsam och tar vanligtvis 10 till 20 \u00e5r - det \u00e4r en betydande flaskhals i pipelinen f\u00f6r l\u00e4kemedelsutveckling. I den h\u00e4r studien anv\u00e4nde forskarna maskininl\u00e4rning (ML) f\u00f6r att p\u00e5skynda uppt\u00e4ckten av nya senolytiska l\u00e4kemedel.\u00a0<\/span><\/p>\n

De tr\u00e4nade AI-modeller p\u00e5 befintliga senolytika och icke-senolytika, vilket gjorde det m\u00f6jligt f\u00f6r AI att skilja mellan dem och f\u00f6ruts\u00e4ga sannolikheten f\u00f6r att molekyler som inte p\u00e5tr\u00e4ffats \u00e4r senolytika.<\/span><\/p>\n

Av 4.340 utv\u00e4rderade molekyler flaggade AI inom 5 minuter f\u00f6r 21 molekyler med h\u00f6g sannolikhet att vara senolytiska.\u00a0<\/span><\/p>\n

En av studiens f\u00f6rfattare, dr Vanessa Smer-Barreto, <\/span>ber\u00e4ttade f\u00f6r The Conversation<\/span><\/a> att om de testades traditionellt i ett laboratorium skulle det kosta 50 000 pund bara att k\u00f6pa in f\u00f6reningarna, exklusive kostnader f\u00f6r utrustning och installation.<\/span><\/p>\n

Efter in vitro-tester p\u00e5 friska och senescenta celler visade det sig att 3 av de 21 molekylerna, periplocin, oleandrin och Linkedin, effektivt eliminerade senescenta celler samtidigt som de normala cellerna skonades.\u00a0<\/span><\/p>\n

I ytterligare tester \u00f6vertr\u00e4ffade oleandrin, en f\u00f6rening som finns i oleanderv\u00e4xten, de mest k\u00e4nda senolytika i sitt slag.<\/span><\/p>\n

Teamet testar nu de tre kandidaterna f\u00f6r senolytika p\u00e5 m\u00e4nsklig lungv\u00e4vnad, och resultaten v\u00e4ntas om cirka tv\u00e5 \u00e5r.<\/span><\/p>\n

Under de senaste m\u00e5naderna har AI <\/span>identifierade potentiella antibiotika<\/span><\/a> som \u00e4r effektivt f\u00f6r att d\u00f6da l\u00e4kemedelsresistenta bakterier, och ett Hongkongbaserat bioteknikf\u00f6retag fick godk\u00e4nnande att inleda kliniska pr\u00f6vningar med en <\/span>AI-uppt\u00e4ckt l\u00e4kemedel<\/span><\/a>.\u00a0<\/span><\/p>\n

AI:s f\u00f6rm\u00e5ga att utf\u00f6ra komplexa analyser av molekyler p\u00e5skyndar i h\u00f6g grad l\u00e4kemedelsutvecklingen och \u00f6ppnar nya m\u00f6jligheter att hantera vanliga och sv\u00e5rbehandlade tillst\u00e5nd och sjukdomar. <\/span><\/p>","protected":false},"excerpt":{"rendered":"

Ett internationellt forskarlag fr\u00e5n University of Edinburgh och det spanska nationella forskningsr\u00e5det IBBTEC-CSIC anv\u00e4nde AI f\u00f6r att p\u00e5skynda uppt\u00e4ckten av l\u00e4kemedel mot \u00e5ldrande. Deras studie identifierade 3 potentiella senolytiska l\u00e4kemedel som kan bromsa \u00e5ldrandet och f\u00f6rebygga \u00e5ldersrelaterade sjukdomar. Dessa l\u00e4kemedel fungerar genom att eliminera senescenta celler, ofta kallade \"zombieceller\". S\u00e5dana celler f\u00f6rblir metaboliskt aktiva men kan inte replikera sig. Att stoppa cellreplikationen fungerar som en f\u00f6rsvarsmekanism f\u00f6r att f\u00f6rhindra att cellskador sprids, men det \u00e4r inte helt okomplicerat. Denna skydds\u00e5tg\u00e4rd \u00e4r i f\u00f6rsta hand utformad f\u00f6r att f\u00f6rhindra spridning av celler som har drabbats av DNA-skador -<\/p>","protected":false},"author":2,"featured_media":2385,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[203,204,105,101],"class_list":["post-2384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-biotech","tag-healthcare","tag-machine-learning","tag-medtech"],"yoast_head":"\nAI accelerates discovery of anti-aging drugs in new study | DailyAI<\/title>\n<meta name=\"description\" content=\"An international team of researchers from the University of Edinburgh and the Spanish National Research Council IBBTEC-CSIC employed AI to accelerate the discovery of anti-aging drugs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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