{"id":2384,"date":"2023-07-07T20:16:06","date_gmt":"2023-07-07T20:16:06","guid":{"rendered":"https:\/\/dailyai.com\/?p=2384"},"modified":"2023-07-07T21:05:18","modified_gmt":"2023-07-07T21:05:18","slug":"ai-accelerates-discovery-of-anti-aging-drugs-in-new-study","status":"publish","type":"post","link":"https:\/\/dailyai.com\/nb\/2023\/07\/ai-accelerates-discovery-of-anti-aging-drugs-in-new-study\/","title":{"rendered":"Ny studie viser at kunstig intelligens fremskynder oppdagelsen av legemidler mot aldring"},"content":{"rendered":"

Et internasjonalt forskerteam fra University of Edinburgh og det spanske nasjonale forskningsr\u00e5det IBBTEC-CSIC har brukt kunstig intelligens for \u00e5 fremskynde oppdagelsen av legemidler mot aldring.\u00a0<\/b><\/p>\n

Deres <\/span>studie<\/span><\/a> har identifisert tre potensielle senolytiske legemidler som kan bremse aldring og forebygge aldersrelaterte sykdommer. Disse legemidlene virker ved \u00e5 eliminere senescente celler, ofte kalt \"zombieceller\". Slike celler forblir metabolsk aktive, men er ute av stand til \u00e5 formere seg.<\/span><\/p>\n

Selv om det \u00e5 stoppe cellereplikasjonen fungerer som en forsvarsmekanisme for \u00e5 hindre spredning av celleskade, er det ikke helt enkelt.\u00a0<\/span><\/p>\n

Dette beskyttelsestiltaket er f\u00f8rst og fremst utformet for \u00e5 hindre spredning av celler som har f\u00e5tt DNA-skader - for eksempel celler som har blitt skadet av sollys. Ved \u00e5 stanse replikasjonen av disse skadede cellene s\u00f8rger kroppen for at skaden ikke sprer seg til flere celler.<\/span><\/p>\n

Disse cellene som har sluttet \u00e5 dele seg, s\u00e5kalte senescente celler, kan imidlertid potensielt for\u00e5rsake skade. N\u00e5r de g\u00e5r inn i senescensfasen, begynner de \u00e5 frigj\u00f8re proteiner som er kjent for \u00e5 for\u00e5rsake betennelse.\u00a0<\/span><\/p>\n

Dette kan p\u00e5virke friske naboceller og potensielt skape et inflammatorisk milj\u00f8.\u00a0<\/span>Over tid kan denne opphopningen av betennelser bidra til ulike helsekomplikasjoner.\u00a0<\/span><\/p>\n

Betennelse er for eksempel knyttet til mange sykdommer, blant annet nevrologiske og degenerative sykdommer, type 2-diabetes, lungefibrose, slitasjegikt og kreft.\u00a0<\/span><\/p>\n

Selv om det er avgj\u00f8rende at cellereplikasjonen stanser for \u00e5 hindre spredning av DNA-skader, kan den inflammatoriske responsen som er forbundet med senescente celler, f\u00f8re til andre helseproblemer hvis den ikke h\u00e5ndteres p\u00e5 riktig m\u00e5te.<\/span><\/p>\n

Og det er her senolytiske legemidler kan hjelpe.\u00a0<\/span><\/p>\n

Rollen til kunstig intelligens<\/span><\/h2>\n

Tidligere forskning p\u00e5 laboratoriemus har vist at senolytiske legemidler forbedrer dette betennelsesscenariet ved \u00e5 eliminere aldrende celler og sk\u00e5ne de friske.\u00a0<\/span><\/p>\n

Det finnes rundt 80 kjente senolytika, men bare en kombinasjon av to av dem, dasatinib og quercetin, har blitt testet p\u00e5 mennesker.\u00a0<\/span><\/p>\n

Oppdagelse av legemidler er sv\u00e6rt kostbart og tar vanligvis 10 til 20 \u00e5r - det er en betydelig flaskehals i legemiddelutviklingen. I denne studien brukte forskerne maskinl\u00e6ring (ML) for \u00e5 fremskynde oppdagelsen av nye senolytiske legemidler.\u00a0<\/span><\/p>\n

De trente AI-modeller p\u00e5 eksisterende senolytiske og ikke-senolytiske stoffer, slik at AI-en kunne skille mellom dem og forutsi sannsynligheten for at molekyler som ikke ble oppdaget, var senolytiske.<\/span><\/p>\n

Av 4340 molekyler som ble evaluert, markerte AI 21 molekyler med h\u00f8y sannsynlighet for \u00e5 v\u00e6re senolytiske i l\u00f8pet av fem minutter.\u00a0<\/span><\/p>\n

En av forfatterne av studien, dr. Vanessa Smer-Barreto, <\/span>fortalte The Conversation<\/span><\/a> at det ville koste 50 000 pund bare \u00e5 kj\u00f8pe inn stoffene, eksklusive kostnader for utstyr og oppsett, hvis de skulle testes p\u00e5 tradisjonelt vis i et laboratorium.<\/span><\/p>\n

Etter in vitro-testing p\u00e5 friske og senescente celler viste det seg at tre av de 21 molekylene, periplocin, oleandrin og Linkedin, effektivt eliminerte senescente celler samtidig som normale celler ble sk\u00e5net.\u00a0<\/span><\/p>\n

I ytterligere tester utkonkurrerte oleandrin, et stoff som finnes i oleanderplanten, de mest kjente senolytiske stoffene av sitt slag.<\/span><\/p>\n

Teamet tester n\u00e5 de tre senolytiske kandidatene p\u00e5 humant lungevev, og resultatene forventes \u00e5 foreligge om rundt to \u00e5r.<\/span><\/p>\n

I l\u00f8pet av de siste par m\u00e5nedene har AI <\/span>identifiserte potensielle antibiotika<\/span><\/a> mot resistente bakterier, og et Hong Kong-basert bioteknologiselskap har f\u00e5tt godkjenning til \u00e5 starte kliniske studier med et <\/span>KI-oppdaget legemiddel<\/span><\/a>.\u00a0<\/span><\/p>\n

AIs evne til \u00e5 utf\u00f8re komplekse analyser av molekyler bidrar til \u00e5 akselerere den farmas\u00f8ytiske utviklingen, noe som \u00e5pner nye muligheter for \u00e5 takle vanlige og vanskelig behandlbare tilstander og sykdommer. <\/span><\/p>","protected":false},"excerpt":{"rendered":"

Et internasjonalt forskerteam fra University of Edinburgh og det spanske nasjonale forskningsr\u00e5det IBBTEC-CSIC har tatt i bruk kunstig intelligens for \u00e5 fremskynde oppdagelsen av legemidler mot aldring. Studien deres identifiserte tre potensielle senolytiske legemidler som kan bremse aldring og forebygge aldersrelaterte sykdommer. Disse legemidlene fungerer ved \u00e5 eliminere senescentceller, ofte kalt \"zombieceller\". Slike celler forblir metabolsk aktive, men er ute av stand til \u00e5 replikere. Selv om det \u00e5 stoppe cellereplikasjonen fungerer som en forsvarsmekanisme for \u00e5 forhindre spredning av celleskade, er det ikke helt enkelt. Dette beskyttelsestiltaket er f\u00f8rst og fremst utformet for \u00e5 hindre spredning av celler som har f\u00e5tt DNA-skader -<\/p>","protected":false},"author":2,"featured_media":2385,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[203,204,105,101],"class_list":["post-2384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-biotech","tag-healthcare","tag-machine-learning","tag-medtech"],"yoast_head":"\nAI accelerates discovery of anti-aging drugs in new study | DailyAI<\/title>\n<meta name=\"description\" content=\"An international team of researchers from the University of Edinburgh and the Spanish National Research Council IBBTEC-CSIC employed AI to accelerate the discovery of anti-aging drugs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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