{"id":10679,"date":"2024-03-12T18:07:19","date_gmt":"2024-03-12T18:07:19","guid":{"rendered":"https:\/\/dailyai.com\/?p=10679"},"modified":"2024-03-13T17:26:08","modified_gmt":"2024-03-13T17:26:08","slug":"researchers-use-ai-to-explore-how-genetics-influence-cardiac-structure","status":"publish","type":"post","link":"https:\/\/dailyai.com\/nb\/2024\/03\/researchers-use-ai-to-explore-how-genetics-influence-cardiac-structure\/","title":{"rendered":"Forskere bruker kunstig intelligens til \u00e5 utforske hvordan genetikk p\u00e5virker hjertets struktur"},"content":{"rendered":"

Et internasjonalt forskerteam har brukt kunstig intelligens til \u00e5 utforske hvordan genetikk p\u00e5virker strukturen i hjertets venstre ventrikkel.<\/b><\/p>\n

Den <\/span>studie<\/span><\/a>Den ble publisert i Nature og ble utf\u00f8rt av University of Manchester i samarbeid med University of Leeds, National Scientific and Technical Research Council i Argentina og IBM Research i California.<\/span><\/p>\n

Forskerne brukte uoverv\u00e5ket dyp l\u00e6ring til \u00e5 analysere over 50 000 3D-MRI-bilder fra UK Biobank, noe som skapte et grunnlag for \u00e5 analysere spesifikke omr\u00e5der av hjertets struktur med tanke p\u00e5 genetiske assosiasjoner ved hjelp av genomomfattende og transkriptomfattende assosiasjonsstudier (GWAS og TWAS).<\/span><\/p>\n

M\u00e5let var \u00e5 finne ut hvordan hjertets struktur er knyttet til genetikk, og dermed \u00e5pne for \u00e5 utforske hvordan genetikk p\u00e5virker organdannelse og -struktur. <\/span><\/p>\n

Dette kan fremme forskningen p\u00e5 ulike former for genetisk betinget medf\u00f8dt hjertesykdom.\u00a0<\/span><\/p>\n

Her er en kort gjennomgang av hvordan det fungerte:<\/span><\/p>\n

    \n
  1. Datainnsamling og forberedelse<\/b>: Teamet begynte med \u00e5 utnytte UK Biobank-databasen, og valgte ut over 50 000 tredimensjonale MR-bilder av hjertet. Disse bildene ga grunnlagsdataene for \u00e5 analysere venstre ventrikkels struktur og morfologi.<\/span><\/li>\n
  2. Oppl\u00e6ring av uoverv\u00e5kede modeller<\/b>: Forskerne brukte deretter uoverv\u00e5kede modeller for dyp l\u00e6ring for \u00e5 l\u00e6re strukturer fra disse bildene, noe som betyr at modellene identifiserte m\u00f8nstre og funksjoner i dataene uten forutg\u00e5ende merking.\u00a0<\/span><\/li>\n
  3. Utvinning av geometriske egenskaper<\/b>: Med de uoverv\u00e5kede modellene p\u00e5 plass fokuserte teamet deretter p\u00e5 \u00e5 trekke ut geometriske funksjoner fra bilder som representerer venstre ventrikkel, hentet fra MR-dataene fra hjertet.\u00a0<\/span><\/li>\n
  4. Genom- og transkriptomomfattende assosiasjonsstudier (GWAS og TWAS)<\/b>: Med de ekstraherte egenskapene gjennomf\u00f8rte forskerne omfattende GWAS- og TWAS-analyser. Disse analysene gjorde det mulig \u00e5 teste sammenhengen mellom genetikk og venstre hjertekammers struktur.\u00a0<\/span><\/li>\n
  5. Resultater<\/b>: 49 nye genetiske lokalisasjoner ble identifisert med sterk sammenheng med hjertets morfologi, og ytterligere 25 var moderat assosiert.\u00a0<\/span><\/li>\n<\/ol>\n

    Professor Alejandro F. Frangi forklarte studien slik: \"Dette er en prestasjon som en gang ville ha virket som science fiction, men vi viser at det er fullt mulig \u00e5 bruke kunstig intelligens til \u00e5 forst\u00e5 det genetiske grunnlaget for venstre hjertekammer, bare ved \u00e5 se p\u00e5 tredimensjonale bilder av hjertet.\"\u00a0<\/span><\/p>\n

    \u00c5 skrive p\u00e5 <\/span>Bloggen til University of Manchester<\/span><\/a>Frangi diskuterte begrensningene ved tidligere studier og gjennombruddene som disse nyere metodene har muliggjort: \"Tidligere studier har bare unders\u00f8kt sammenhengen mellom tradisjonelle kliniske fenotyper ... I denne studien har vi imidlertid ikke bare brukt kunstig intelligens til \u00e5 avgrense hjertekamrene fra tredimensjonale medisinske bilder i h\u00f8yt tempo, men ogs\u00e5 til \u00e5 avdekke nye genetiske loci som er assosiert med ulike dype kardiovaskul\u00e6re fenotyper.\"<\/span><\/p>\n

    Funnene i studien gir innsikt i det genetiske grunnlaget for hjerte- og karsykdommer og \u00e5pner nye muligheter for utvikling av m\u00e5lrettede behandlingsformer og presisjonsmedisin.\u00a0<\/span><\/p>\n

    Professor Bryan Williams fra British Heart Foundation sier: \"Denne nye forskningen viser den enorme kraften i stordata som knytter gener til hjertets struktur. Maskinl\u00e6ring har gjort dette mulig ved \u00e5 endre hvordan vi behandler, analyserer og f\u00e5r innsikt fra stordata for \u00e5 l\u00f8se de st\u00f8rste sp\u00f8rsm\u00e5lene innen kardiovaskul\u00e6r forskning.\"\u00a0<\/span><\/p>\n

    AI-modeller har tidligere blitt brukt til \u00e5 produsere detaljerte 3D-kart av organer, inkludert menneskehjernen, for eksempel i EUs <\/span>Human Brain Project (HBP) i stor skala<\/span><\/a>.\u00a0<\/span><\/p>\n

    Dette g\u00e5r et skritt videre n\u00e5r det gjelder \u00e5 knytte genetikk til organstruktur, og gir en dypere forst\u00e5else av hjertets morfologi og dets genetiske drivkrefter.<\/span><\/p>","protected":false},"excerpt":{"rendered":"

    Et internasjonalt forskerteam har brukt kunstig intelligens til \u00e5 utforske hvordan genetikk p\u00e5virker strukturen i hjertets venstre ventrikkel. Studien, som er publisert i Nature, ble utf\u00f8rt av University of Manchester i samarbeid med University of Leeds, National Scientific and Technical Research Council i Argentina og IBM Research i California. Forskerne brukte uoverv\u00e5ket dyp l\u00e6ring til \u00e5 analysere over 50 000 3D-MRI-bilder fra UK Biobank, noe som skapte et grunnlag for \u00e5 analysere spesifikke omr\u00e5der av hjertets struktur med tanke p\u00e5 genetiske assosiasjoner ved hjelp av genomomfattende og transkriptomfattende assosiasjonsstudier (GWAS og TWAS). M\u00e5let var \u00e5 finne ut hvordan hjertets struktur er knyttet til<\/p>","protected":false},"author":2,"featured_media":10680,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[203,204,178],"class_list":["post-10679","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-biotech","tag-healthcare","tag-medicine"],"yoast_head":"\nResearchers use AI to explore how genetics influence cardiac structure | DailyAI<\/title>\n<meta name=\"description\" content=\"An international research team used AI to explore how genetics influence the structure of the heart's left ventricle.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dailyai.com\/nb\/2024\/03\/researchers-use-ai-to-explore-how-genetics-influence-cardiac-structure\/\" 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