{"id":2384,"date":"2023-07-07T20:16:06","date_gmt":"2023-07-07T20:16:06","guid":{"rendered":"https:\/\/dailyai.com\/?p=2384"},"modified":"2023-07-07T21:05:18","modified_gmt":"2023-07-07T21:05:18","slug":"ai-accelerates-discovery-of-anti-aging-drugs-in-new-study","status":"publish","type":"post","link":"https:\/\/dailyai.com\/fr\/2023\/07\/ai-accelerates-discovery-of-anti-aging-drugs-in-new-study\/","title":{"rendered":"Une nouvelle \u00e9tude montre que l'IA acc\u00e9l\u00e8re la d\u00e9couverte de m\u00e9dicaments antivieillissement"},"content":{"rendered":"

Une \u00e9quipe internationale de chercheurs de l'universit\u00e9 d'\u00c9dimbourg et du Conseil national de la recherche espagnol IBBTEC-CSIC a utilis\u00e9 l'IA pour acc\u00e9l\u00e9rer la d\u00e9couverte de m\u00e9dicaments antivieillissement.\u00a0<\/b><\/p>\n

Leur <\/span>\u00e9tude<\/span><\/a> a identifi\u00e9 trois m\u00e9dicaments s\u00e9nolytiques potentiels capables de ralentir le vieillissement et de pr\u00e9venir les maladies li\u00e9es \u00e0 l'\u00e2ge. Ces m\u00e9dicaments agissent en \u00e9liminant les cellules s\u00e9nescentes, souvent appel\u00e9es \"cellules zombies\". Ces cellules restent m\u00e9taboliquement actives mais sont incapables de se r\u00e9pliquer.<\/span><\/p>\n

L'arr\u00eat de la r\u00e9plication cellulaire est un m\u00e9canisme d\u00e9fensif qui permet d'\u00e9viter la propagation des l\u00e9sions cellulaires, mais ce n'est pas tout \u00e0 fait simple.\u00a0<\/span><\/p>\n

Cette mesure de protection est principalement destin\u00e9e \u00e0 emp\u00eacher la prolif\u00e9ration des cellules dont l'ADN a \u00e9t\u00e9 endommag\u00e9 - par exemple, les cellules qui ont \u00e9t\u00e9 endommag\u00e9es par l'exposition \u00e0 la lumi\u00e8re du soleil. En stoppant la r\u00e9plication de ces cellules endommag\u00e9es, l'organisme s'assure que ces dommages ne se propagent pas \u00e0 d'autres cellules.<\/span><\/p>\n

Cependant, ces cellules qui ont cess\u00e9 de se diviser, appel\u00e9es cellules s\u00e9nescentes, peuvent potentiellement causer des dommages. Lorsqu'elles entrent en phase de s\u00e9nescence, elles commencent \u00e0 lib\u00e9rer des prot\u00e9ines connues pour provoquer des inflammations.\u00a0<\/span><\/p>\n

Cela peut affecter les cellules saines voisines, cr\u00e9ant potentiellement un environnement inflammatoire.\u00a0<\/span>Au fil du temps, cette accumulation d'inflammation peut contribuer \u00e0 diverses complications de sant\u00e9.\u00a0<\/span><\/p>\n

Par exemple, l'inflammation est li\u00e9e \u00e0 de nombreuses maladies, notamment les maladies neurologiques et d\u00e9g\u00e9n\u00e9ratives, le diab\u00e8te de type 2, la fibrose pulmonaire, l'arthrose et le cancer.\u00a0<\/span><\/p>\n

Par cons\u00e9quent, si l'arr\u00eat de la r\u00e9plication cellulaire est essentiel pour pr\u00e9venir la propagation des l\u00e9sions de l'ADN, la r\u00e9action inflammatoire associ\u00e9e aux cellules s\u00e9nescentes peut entra\u00eener d'autres probl\u00e8mes de sant\u00e9 si elle n'est pas correctement prise en charge.<\/span><\/p>\n

C'est l\u00e0 que les m\u00e9dicaments s\u00e9nolytiques peuvent \u00eatre utiles.\u00a0<\/span><\/p>\n

Le r\u00f4le de l'IA<\/span><\/h2>\n

Des recherches ant\u00e9rieures sur des souris de laboratoire ont d\u00e9montr\u00e9 que les m\u00e9dicaments s\u00e9nolytiques am\u00e9liorent ce sc\u00e9nario inflammatoire en \u00e9liminant les cellules s\u00e9nescentes et en \u00e9pargnant les cellules saines.\u00a0<\/span><\/p>\n

Bien qu'il existe environ 80 s\u00e9nolytiques connus, seule une combinaison de deux d'entre eux, le dasatinib et la querc\u00e9tine, a \u00e9t\u00e9 test\u00e9e chez l'homme.\u00a0<\/span><\/p>\n

La d\u00e9couverte de m\u00e9dicaments est exceptionnellement co\u00fbteuse et prend g\u00e9n\u00e9ralement de 10 \u00e0 20 ans - c'est un goulot d'\u00e9tranglement important dans le pipeline de d\u00e9veloppement des m\u00e9dicaments. Dans cette \u00e9tude, les chercheurs ont utilis\u00e9 l'apprentissage automatique pour acc\u00e9l\u00e9rer la d\u00e9couverte de nouveaux m\u00e9dicaments s\u00e9nolytiques.\u00a0<\/span><\/p>\n

Ils ont form\u00e9 des mod\u00e8les d'IA sur des mol\u00e9cules s\u00e9nolytiques et non s\u00e9nolytiques existantes, ce qui a permis \u00e0 l'IA de les distinguer et de pr\u00e9dire la probabilit\u00e9 que des mol\u00e9cules non rencontr\u00e9es soient s\u00e9nolytiques.<\/span><\/p>\n

Sur les 4 340 mol\u00e9cules \u00e9valu\u00e9es, l'IA en a rep\u00e9r\u00e9 21 qui avaient une forte probabilit\u00e9 d'\u00eatre s\u00e9nolytiques en moins de 5 minutes.\u00a0<\/span><\/p>\n

L'un des auteurs de l'\u00e9tude, le Dr Vanessa Smer-Barreto, <\/span>a d\u00e9clar\u00e9 \u00e0 The Conversation<\/span><\/a> que, s'ils \u00e9taient test\u00e9s traditionnellement en laboratoire, il faudrait 50 000 livres sterling rien que pour acheter les compos\u00e9s, sans compter le co\u00fbt de l'\u00e9quipement et de l'installation.<\/span><\/p>\n

Apr\u00e8s des tests in vitro sur des cellules saines et s\u00e9nescentes, 3 des 21 mol\u00e9cules, periplocin, oleandrin et Linkedin, ont \u00e9limin\u00e9 efficacement les cellules s\u00e9nescentes tout en \u00e9pargnant les cellules normales.\u00a0<\/span><\/p>\n

Lors de tests compl\u00e9mentaires, l'ol\u00e9andrine, un compos\u00e9 pr\u00e9sent dans le laurier-rose, a surpass\u00e9 les s\u00e9nolytiques les plus connus de sa cat\u00e9gorie.<\/span><\/p>\n

L'\u00e9quipe teste actuellement les trois candidats s\u00e9nolytiques sur des tissus pulmonaires humains, et les r\u00e9sultats sont attendus dans environ deux ans.<\/span><\/p>\n

Au cours des derniers mois, l'IA a <\/span>antibiotiques potentiels identifi\u00e9s<\/span><\/a> efficace pour tuer les bact\u00e9ries r\u00e9sistantes aux m\u00e9dicaments, et une soci\u00e9t\u00e9 de biotechnologie bas\u00e9e \u00e0 Hong Kong a re\u00e7u l'autorisation d'entamer des essais cliniques avec une mol\u00e9cule de type <\/span>M\u00e9dicament d\u00e9couvert par l'IA<\/span><\/a>.\u00a0<\/span><\/p>\n

La capacit\u00e9 de l'IA \u00e0 effectuer des analyses complexes de mol\u00e9cules acc\u00e9l\u00e8re consid\u00e9rablement les pipelines de d\u00e9veloppement pharmaceutique, ce qui ouvre de nouvelles perspectives pour s'attaquer \u00e0 des affections et maladies courantes et difficiles \u00e0 traiter. <\/span><\/p>","protected":false},"excerpt":{"rendered":"

Une \u00e9quipe internationale de chercheurs de l'universit\u00e9 d'\u00c9dimbourg et du Conseil national de la recherche espagnol IBBTEC-CSIC a utilis\u00e9 l'IA pour acc\u00e9l\u00e9rer la d\u00e9couverte de m\u00e9dicaments antivieillissement. Leur \u00e9tude a permis d'identifier trois m\u00e9dicaments s\u00e9nolytiques potentiels capables de ralentir le vieillissement et de pr\u00e9venir les maladies li\u00e9es \u00e0 l'\u00e2ge. Ces m\u00e9dicaments agissent en \u00e9liminant les cellules s\u00e9nescentes, souvent appel\u00e9es \"cellules zombies\". Ces cellules restent m\u00e9taboliquement actives mais sont incapables de se r\u00e9pliquer. Si l'arr\u00eat de la r\u00e9plication cellulaire constitue un m\u00e9canisme de d\u00e9fense pour emp\u00eacher la propagation des l\u00e9sions cellulaires, ce n'est pas tout \u00e0 fait simple. Cette mesure de protection est principalement con\u00e7ue pour emp\u00eacher la prolif\u00e9ration des cellules dont l'ADN a \u00e9t\u00e9 endommag\u00e9.<\/p>","protected":false},"author":2,"featured_media":2385,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[203,204,105,101],"class_list":["post-2384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-biotech","tag-healthcare","tag-machine-learning","tag-medtech"],"yoast_head":"\nAI accelerates discovery of anti-aging drugs in new study | DailyAI<\/title>\n<meta name=\"description\" content=\"An international team of researchers from the University of Edinburgh and the Spanish National Research Council IBBTEC-CSIC employed AI to accelerate the discovery of anti-aging drugs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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