{"id":2282,"date":"2023-07-04T08:09:00","date_gmt":"2023-07-04T08:09:00","guid":{"rendered":"https:\/\/dailyai.com\/?p=2282"},"modified":"2023-07-05T08:09:37","modified_gmt":"2023-07-05T08:09:37","slug":"first-ai-generated-drug-given-go-ahead-for-human-trials","status":"publish","type":"post","link":"https:\/\/dailyai.com\/de\/2023\/07\/first-ai-generated-drug-given-go-ahead-for-human-trials\/","title":{"rendered":"Erstes KI-generiertes Medikament erh\u00e4lt gr\u00fcnes Licht f\u00fcr Versuche am Menschen"},"content":{"rendered":"<p><strong>Insilico Medicine hat die Zulassung f\u00fcr die Erprobung seines vollst\u00e4ndig von der KI generierten Medikaments am Menschen erhalten.<\/strong><\/p>\n<p><span style=\"font-weight: 400;\">Das Medikament wurde als potenzielle Behandlung f\u00fcr die idiopathische Lungenfibrose (IPF) entwickelt, eine degenerative Erkrankung, die zur Vernarbung und Verdickung des Lungengewebes f\u00fchrt. Von IPF sind allein in den USA rund 100 000 Menschen betroffen. Das neue Medikament mit der Bezeichnung INS018_055 wird 12 Wochen lang in China erprobt; weitere Versuche sind in China und den USA geplant.<\/span><\/p>\n<p><a href=\"https:\/\/insilico.com\/\"><span style=\"font-weight: 400;\">Insilico<\/span><\/a><span style=\"font-weight: 400;\"> ist ein in Hongkong ans\u00e4ssiges Biotech-Unternehmen, das KI f\u00fcr die Entwicklung neuer Medikamente und f\u00fcr die Anti-Aging-Forschung einsetzt. Die Anwendung von KI in der Forschung hat eine wesentlich schnellere Entwicklung neuer Medikamente erm\u00f6glicht.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\"KI erm\u00f6glicht es uns, riesige Datenmengen zu analysieren und Zusammenh\u00e4nge zu finden, die menschlichen Wissenschaftlern entgehen k\u00f6nnten, und dann v\u00f6llig neue Molek\u00fcle zu 'erfinden', die in Medikamente umgewandelt werden k\u00f6nnen\", sagte Alex Zhavoronkov, Gr\u00fcnder und CEO von Insilico Medicine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Das Unternehmen nutzt KI in jedem Schritt seiner Strategie zur Arzneimittelentwicklung. Zun\u00e4chst setzt es sein KI-gest\u00fctztes Tool namens PandaOmics ein, um ein \"Ziel\" oder eine biologische Ursache zu identifizieren, die mit einer bestimmten Krankheit verbunden ist. Das Ziel k\u00f6nnte zum Beispiel ein Gen oder ein Protein sein, das nicht richtig funktioniert.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sobald sie ein Ziel identifiziert haben, nutzen sie ihre andere KI-Plattform, Chemistry42, um ein Molek\u00fcl zu entwickeln, das das Problem behebt, indem es das Ziel blockiert, ohne dem Patienten zu schaden.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In diesem Fall bezieht sich die \"55\" im Medikamentennamen auf das 55. Molek\u00fcl, das entwickelt wurde und vielversprechend war.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Die genehmigten Phase-II-Studien zielen darauf ab, festzustellen, ob das Medikament bei den ersten Teilnehmern eine signifikante Reaktion hervorruft. Im Erfolgsfall werden dann Phase-III-Studien durchgef\u00fchrt, um die Sicherheit und Wirksamkeit zu best\u00e4tigen, bevor die FDA die Zulassung erteilt.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Insilico Medicine hat eine Reihe interessanter KI-Arzneimittelentwicklungen in der Pipeline. Die FDA hat vor kurzem den ersten IND-Antrag (Investigational New Drug) f\u00fcr ihr Krebsmedikament genehmigt, das auf solide Tumore abzielt. Phase-I-Studien sind f\u00fcr Juli 2023 in den USA und China geplant.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wenn wir von generativer KI h\u00f6ren, denken wir normalerweise an Bilder, Lieder oder Texte, die generiert werden. Aber Insilico nutzt generative KI, um die Ziele zu identifizieren, die eine Krankheit verursachen, und dann Molek\u00fcle zu entwickeln, die diese Ziele direkt ansprechen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wenn Sie ChatGPT fragen, welche Proteine f\u00fcr die Behandlung einer bestimmten Art von Brustkrebs in Frage kommen, kann es diese identifizieren, da es Zugang zu ver\u00f6ffentlichten medizinischen Forschungsergebnissen hat. Insilico verf\u00fcgt \u00fcber ein eigenes LLM namens ChatPandaGPT, das es Forschern erm\u00f6glicht, mit nat\u00fcrlichsprachlichen Abfragen eine spezialisierte Wissensdatenbank mit gro\u00dfen Mengen klinischer Daten zu durchforsten.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Verwendung von <\/span><a href=\"https:\/\/dailyai.com\/de\/2023\/06\/researchers-create-high-performance-ai-model-to-detect-heart-disease-from-ecgs\/\"><span style=\"font-weight: 400;\">KI in der Medizin<\/span><\/a><span style=\"font-weight: 400;\"> hilft Unternehmen wie Insilico, den Prozess der Arzneimittelentdeckung drastisch zu verk\u00fcrzen. Ihr <\/span><a href=\"https:\/\/insilico.com\/pipeline\"><span style=\"font-weight: 400;\">Forschungspipeline<\/span><\/a><span style=\"font-weight: 400;\"> verf\u00fcgt \u00fcber eine Reihe interessanter potenzieller Behandlungen f\u00fcr verschiedene Krebsarten sowie ein COVID-19-Medikament, das sich ebenfalls in Phase-I-Studien befindet.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Insilico Medicine hat die Zulassung f\u00fcr die Erprobung seines vollst\u00e4ndig durch KI erzeugten Medikaments am Menschen erhalten. Das Medikament wurde als potenzielle Behandlung f\u00fcr idiopathische Lungenfibrose (IPF) entwickelt. IPF ist eine degenerative Erkrankung, die zu Vernarbung und Verdickung des Lungengewebes f\u00fchrt. Von IPF sind allein in den USA rund 100 000 Menschen betroffen. Das neue Medikament mit der Bezeichnung INS018_055 wird 12 Wochen lang in China erprobt; weitere Versuche sind in China und den USA geplant. Insilico ist ein in Hongkong ans\u00e4ssiges Biotech-Unternehmen, das KI zur Entwicklung neuer Medikamente und in der Anti-Aging-Forschung einsetzt. Die Anwendung von KI in ihrem<\/p>","protected":false},"author":6,"featured_media":2283,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[150,107,101],"class_list":["post-2282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-ai-benefits","tag-generative-ai","tag-medtech"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First AI-generated drug given go-ahead for human trials | DailyAI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dailyai.com\/de\/2023\/07\/first-ai-generated-drug-given-go-ahead-for-human-trials\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First AI-generated drug given go-ahead for human trials | DailyAI\" \/>\n<meta property=\"og:description\" content=\"Insilico Medicine has been given approval for human trials of their completely AI-generated drug. The drug has been designed as a potential treatment for idiopathic pulmonary fibrosis (IPF) which is a degenerative disease that causes scarring and thickening of the lung tissues. IPF affects around 100,000 people in the US alone. The new drug, called INS018_055, will be trialed for 12 weeks in China with expanded trials planned for China and the US. Insilico is a Hong Kong based biotech company that uses AI to develop new medicines as well as in anti-aging research. 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