{"id":9968,"date":"2024-02-13T13:08:02","date_gmt":"2024-02-13T13:08:02","guid":{"rendered":"https:\/\/dailyai.com\/?p=9968"},"modified":"2024-02-13T13:08:02","modified_gmt":"2024-02-13T13:08:02","slug":"gpt-4v-offers-big-benefits-in-clinical-trial-screening","status":"publish","type":"post","link":"https:\/\/dailyai.com\/da\/2024\/02\/gpt-4v-offers-big-benefits-in-clinical-trial-screening\/","title":{"rendered":"GPT-4V giver store fordele ved screening af kliniske fors\u00f8g"},"content":{"rendered":"<p><strong>Screening af patienter for at finde egnede deltagere til kliniske fors\u00f8g er en arbejdskr\u00e6vende, dyr og fejlbeh\u00e6ftet opgave, men AI kan snart l\u00f8se det.<\/strong><\/p>\n<p>Et hold forskere fra Brigham and Women's Hospital, Harvard Medical School og Mass General Brigham Personalized Medicine gennemf\u00f8rte en unders\u00f8gelse for at se, om en AI-model kunne behandle l\u00e6gejournaler for at finde egnede kandidater til kliniske fors\u00f8g.<\/p>\n<p>De brugte GPT-4V, OpenAI's LLM med billedbehandling, aktiveret af Retrieval-Augmented Generation (RAG) til at behandle potentielle kandidaters elektroniske sundhedsjournaler (EHR) og kliniske notater.<\/p>\n<p>LLM'er er tr\u00e6net p\u00e5 forh\u00e5nd ved hj\u00e6lp af et fast datas\u00e6t og kan kun besvare sp\u00f8rgsm\u00e5l baseret p\u00e5 disse data. RAG er en teknik, der g\u00f8r det muligt for en LLM at hente data fra eksterne datakilder som internettet eller en organisations interne dokumenter.<\/p>\n<p>N\u00e5r deltagere udv\u00e6lges til et klinisk fors\u00f8g, afg\u00f8res deres egnethed ud fra en liste med inklusions- og eksklusionskriterier. Det indeb\u00e6rer normalt, at uddannet personale fink\u00e6mmer hundredvis eller tusindvis af patienters EPJ'er for at finde dem, der matcher kriterierne.<\/p>\n<p>Forskerne indsamlede data fra et fors\u00f8g, der havde til form\u00e5l at rekruttere patienter med symptomatisk hjertesvigt. De brugte disse data til at se, om GPT-4V med RAG kunne g\u00f8re arbejdet mere effektivt end fors\u00f8gspersonalet, samtidig med at n\u00f8jagtigheden blev opretholdt.<\/p>\n<p>De strukturerede data i de potentielle kandidaters EPJ'er kan bruges til at fastl\u00e6gge 5 ud af 6 inklusionskriterier og 5 ud af 17 eksklusionskriterier for det kliniske fors\u00f8g. Det er den nemme del.<\/p>\n<p>De resterende 13 kriterier skulle bestemmes ved at unders\u00f8ge ustrukturerede data i hver patients kliniske noter, hvilket er den arbejdskr\u00e6vende del, som forskerne h\u00e5bede, at AI kunne hj\u00e6lpe med.<\/p>\n<blockquote class=\"twitter-tweet\">\n<p dir=\"ltr\" lang=\"en\">\ud83d\udd0dKan <a href=\"https:\/\/twitter.com\/Microsoft?ref_src=twsrc%5Etfw\">@Microsoft<\/a> <a href=\"https:\/\/twitter.com\/Azure?ref_src=twsrc%5Etfw\">@Azure<\/a> <a href=\"https:\/\/twitter.com\/OpenAI?ref_src=twsrc%5Etfw\">@OpenAI<\/a>'s <a href=\"https:\/\/twitter.com\/hashtag\/GPT4?src=hash&amp;ref_src=twsrc%5Etfw\">#GPT4<\/a> pr\u00e6stere bedre end et menneske til screening af kliniske fors\u00f8g? Det sp\u00f8rgsm\u00e5l stillede vi i vores seneste unders\u00f8gelse, og jeg er meget begejstret for at kunne dele vores resultater i preprint:<a href=\"https:\/\/t.co\/lhOPKCcudP\">https:\/\/t.co\/lhOPKCcudP<\/a><br \/>\nAt integrere GPT4 i kliniske fors\u00f8g er ikke...<\/p>\n<p>- Ozan Unlu (@OzanUnluMD) <a href=\"https:\/\/twitter.com\/OzanUnluMD\/status\/1756085573134250256?ref_src=twsrc%5Etfw\">9. februar 2024<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<h2>Resultater<\/h2>\n<p>Forskerne indhentede f\u00f8rst strukturerede vurderinger udf\u00f8rt af studiepersonalet og kliniske notater for de sidste to \u00e5r.<\/p>\n<p>De udviklede en arbejdsgang til et klinisk notatbaseret sp\u00f8rgsm\u00e5l-svar-system, der er drevet af RAG-arkitektur og GPT-4V, og kaldte denne arbejdsgang RECTIFIER (RAG-Enabled Clinical Trial Infrastructure for Inclusion Exclusion Review).<\/p>\n<p>Noter fra 100 patienter blev brugt som udviklingsdatas\u00e6t, 282 patienter som valideringsdatas\u00e6t og 1894 patienter som tests\u00e6t.<\/p>\n<p>En klinisk ekspert gennemf\u00f8rte en blindet gennemgang af patienternes journaler for at besvare sp\u00f8rgsm\u00e5lene om berettigelse og bestemme \"guldstandard\"-svarene. Disse blev derefter sammenlignet med svarene fra fors\u00f8gspersonalet og RECTIFIER baseret p\u00e5 f\u00f8lgende kriterier:<\/p>\n<ul>\n<li>Sensitivitet - En tests evne til korrekt at identificere patienter, der er kvalificerede til fors\u00f8get (sande positive).<\/li>\n<li>Specificitet - En tests evne til korrekt at identificere patienter, der ikke er kvalificerede til fors\u00f8get (\u00e6gte negative).<\/li>\n<li>N\u00f8jagtighed - Den samlede andel af korrekte klassifikationer (b\u00e5de sande positive og sande negative).<\/li>\n<li>Matthews korrelationskoefficient (MCC) - En metrik, der bruges til at m\u00e5le, hvor god modellen var til at v\u00e6lge eller udelukke en person. En v\u00e6rdi p\u00e5 0 er det samme som et m\u00f8ntkast, og 1 betyder, at man rammer rigtigt 100% af gangene.<\/li>\n<\/ul>\n<figure id=\"attachment_9971\" aria-describedby=\"caption-attachment-9971\" style=\"width: 1538px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9971 size-full\" src=\"https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff.png\" alt=\"\" width=\"1538\" height=\"654\" srcset=\"https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff.png 1538w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-300x128.png 300w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-1024x435.png 1024w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-768x327.png 768w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-1536x653.png 1536w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-370x157.png 370w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-800x340.png 800w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-740x315.png 740w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-20x9.png 20w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/02\/RECTIFIER-vs-Study-staff-113x48.png 113w\" sizes=\"auto, (max-width: 1538px) 100vw, 1538px\" \/><figcaption id=\"caption-attachment-9971\" class=\"wp-caption-text\">Pr\u00e6stationsm\u00e5linger af RECTIFIER og Study Staff for at bestemme den samlede berettigelse baseret p\u00e5 13 sp\u00f8rgsm\u00e5l i tests\u00e6ttet. Kilde: arXiv<\/figcaption><\/figure>\n<p>RECTIFIER klarede sig lige s\u00e5 godt, og i nogle tilf\u00e6lde bedre, end studiepersonalet. Det mest betydningsfulde resultat af unders\u00f8gelsen kom sandsynligvis fra omkostningssammenligningen.<\/p>\n<p>Der blev ikke oplyst tal for afl\u00f8nningen af fors\u00f8gspersonalet, men det m\u00e5 have v\u00e6ret betydeligt mere end omkostningerne ved at bruge GPT-4V, som varierede mellem $0,02 og $0,10 pr. patient. At bruge AI til at evaluere en pulje p\u00e5 1.000 potentielle kandidater ville tage et par minutter og koste omkring $100.<\/p>\n<p>Forskerne konkluderede, at brugen af en AI-model som GPT-4V med RAG kan opretholde eller forbedre n\u00f8jagtigheden i identifikationen af kandidater til kliniske fors\u00f8g og g\u00f8re det mere effektivt og meget billigere end at bruge menneskelige medarbejdere.<\/p>\n<p>De bem\u00e6rkede, at man skal v\u00e6re forsigtig med at overlade l\u00e6gehj\u00e6lp til automatiserede systemer, men det ser ud til, at AI vil g\u00f8re et bedre stykke arbejde, end vi kan, hvis det styres korrekt.<\/p>","protected":false},"excerpt":{"rendered":"<p>Screening af patienter for at finde egnede deltagere til kliniske fors\u00f8g er en arbejdskr\u00e6vende, dyr og fejlbeh\u00e6ftet opgave, men det kan AI snart g\u00f8re noget ved. Et hold forskere fra Brigham and Women's Hospital, Harvard Medical School og Mass General Brigham Personalized Medicine gennemf\u00f8rte en unders\u00f8gelse for at se, om en AI-model kunne behandle l\u00e6gejournaler for at finde egnede kandidater til kliniske fors\u00f8g. De brugte GPT-4V, OpenAI's LLM med billedbehandling, aktiveret af Retrieval-Augmented Generation (RAG) til at behandle potentielle kandidaters elektroniske patientjournaler (EHR) og kliniske notater. LLM'er er tr\u00e6net p\u00e5 forh\u00e5nd ved hj\u00e6lp af et fast datas\u00e6t og kan kun besvare sp\u00f8rgsm\u00e5l baseret p\u00e5 disse data. RAG<\/p>","protected":false},"author":6,"featured_media":9972,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[150,204,101],"class_list":["post-9968","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-ai-benefits","tag-healthcare","tag-medtech"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GPT-4V offers big benefits in clinical trial screening | DailyAI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dailyai.com\/da\/2024\/02\/gpt-4v-offers-big-benefits-in-clinical-trial-screening\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GPT-4V offers big benefits in clinical trial screening | DailyAI\" \/>\n<meta property=\"og:description\" content=\"Screening patients to find suitable participants for clinical trials is a labor-intensive, expensive, and error-prone task but AI could soon fix that. A team of researchers from Brigham and Women\u2019s Hospital, Harvard Medical School, and Mass General Brigham Personalized Medicine, conducted a study to see if an AI model could process medical records to find suitable clinical trial candidates. They used GPT-4V, OpenAI\u2019s LLM with image processing, enabled by Retrieval-Augmented Generation (RAG) to process potential candidates&#8217; electronic health records (EHR) and clinical notes. LLMs are pre-trained using a fixed dataset and can only answer questions based on that data. 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