{"id":4779,"date":"2023-08-28T19:26:58","date_gmt":"2023-08-28T19:26:58","guid":{"rendered":"https:\/\/dailyai.com\/?p=4779"},"modified":"2023-08-28T22:45:53","modified_gmt":"2023-08-28T22:45:53","slug":"stanford-scientists-develop-ai-model-for-predicting-glioblastoma-outcomes","status":"publish","type":"post","link":"https:\/\/dailyai.com\/da\/2023\/08\/stanford-scientists-develop-ai-model-for-predicting-glioblastoma-outcomes\/","title":{"rendered":"Stanford-forskere udvikler AI-model til forudsigelse af glioblastom-resultater"},"content":{"rendered":"<p><b>Forskere fra Stanford Medicine har udviklet en AI-model, der er designet til at forbedre diagnosticeringen og behandlingen af glioblastom, en s\u00e6rlig aggressiv form for hjernekr\u00e6ft.\u00a0<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Glioblastom giver unikke udfordringer for l\u00e6gerne p\u00e5 grund af den meget varierende cellul\u00e6re sammens\u00e6tning fra patient til patient.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Olivier Gevaert, lektor i biomedicinsk informatik og datavidenskab, fremh\u00e6vede kompleksiteten i behandlingen af glioblastom og sagde: \"P\u00e5 grund af denne sygdoms heterogenitet har forskerne ikke fundet gode m\u00e5der at tackle den p\u00e5.\"<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Den <\/span><a href=\"https:\/\/med.stanford.edu\/news\/all-news\/2023\/08\/ai-brain-cancer-glioblastoma.html\"><span style=\"font-weight: 400;\">AI-model<\/span><\/a><span style=\"font-weight: 400;\"> sigter mod at afhj\u00e6lpe dette problem ved at analysere farvede billeder af glioblastomv\u00e6v for at vurdere dets egenskaber, herunder tumorens aggressivitet og genetiske sammens\u00e6tning.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Yuanning Zheng, fra Gevaerts laboratorium, <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-39933-0\"><span style=\"font-weight: 400;\">beskrevet<\/span><\/a><span style=\"font-weight: 400;\"> AI-systemet som \"en slags beslutningsst\u00f8ttesystem for l\u00e6gerne\".\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Modellen kan hj\u00e6lpe klinikere med at identificere patienter med cellul\u00e6re karakteristika, der tyder p\u00e5 mere aggressive tumorer, og markere dem til hurtig opf\u00f8lgning. Det k<\/span><span style=\"font-weight: 400;\">reates et mere detaljeret kort over tumoren, der afsl\u00f8rer celle-til-celle-interaktioner, og hvordan disse korrelerer med patientresultater.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gevaert uddyber: \"Modellen viste, hvilke celler der kan lide at v\u00e6re sammen, hvilke celler der ikke \u00f8nsker at kommunikere, og hvordan det h\u00e6nger sammen med patientresultaterne.\"\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For eksempel fandt modellen, at klyngen af specifikke celler, kendt som astrocytter, indikerede en mere aggressiv form for kr\u00e6ft. Denne indsigt kan potentielt hj\u00e6lpe med at designe mere effektive behandlinger af glioblastom.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zheng h\u00e5ber, at modellen ogs\u00e5 kan tjene som et postoperativt vurderingsv\u00e6rkt\u00f8j. Modellen viste, at tumorceller, der viste tegn p\u00e5 iltmangel, ofte korrelerede med d\u00e5rligere kr\u00e6ftresultater.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\"Ved at belyse de iltfattige celler i histologisk farvede operationspr\u00f8ver kan modellen hj\u00e6lpe kirurgerne med at forst\u00e5, hvor mange kr\u00e6ftceller der kan v\u00e6re tilbage i hjernen, og hvor hurtigt de skal genoptage behandlingen efter operationen,\" siger Zheng.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"> Modellen er stadig i forskningsfasen, men den har potentiale til at blive anvendt p\u00e5 andre kr\u00e6ftformer, f.eks. bryst- eller lungekr\u00e6ft.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"> Zheng konkluderede: \"Jeg tror, at disse multimodale dataintegrationer kan forme forbedringen af personlig medicin i fremtiden.\"<\/span><\/p>\n<p><span style=\"font-weight: 400;\">I \u00f8jeblikket er en proof-of-concept-version af deres model, kaldet GBM360, tilg\u00e6ngelig for forskere, der kan teste og uploade diagnostiske billeder for at forudsige glioblastompatienters resultater. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zheng skyndte sig dog at tilf\u00f8je, at modellen stadig er i forskningsfasen og ikke bruges i virkelige kliniske omgivelser.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Mere om unders\u00f8gelsen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Unders\u00f8gelsen bruger AI til at fortolke glioblastom-undertyper ud fra eksisterende patientdata, hvilket hj\u00e6lper klinikere med at bestemme sygdomsprognose og -udvikling for forskellige patienter.\u00a0<\/span><\/p>\n<p>S\u00e5dan her fungerer det:<\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>Integration af data<\/strong>: Forskerne begyndte med at integrere flere former for data, herunder enkeltcelle-RNA-sekventering og rumlig transkriptomik, sammen med kliniske resultater fra glioblastompatienter. Dette gav et robust datas\u00e6t til udvikling af maskinl\u00e6ringsmodeller (ML).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>Udvikling af modeller<\/strong>: Teamet udviklede GBM-CNN, en specialiseret deep-learning-model, der er designet til at fortolke histologibilleder. Denne model blev tr\u00e6net til at forudsige de forskellige transkriptionelle undertyper af glioblastomceller ved hj\u00e6lp af de integrerede data til validering.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>Analyse i stor skala<\/strong>: Efter tr\u00e6ning blev GBM-CNN brugt til at analysere over 40 millioner v\u00e6vspletter fra 410 patienter, hvilket skabte cellul\u00e6re kort i h\u00f8j opl\u00f8sning. Analysen afsl\u00f8rede tilstedev\u00e6relsen af tre til fem ondartede undertyper i hver tumor.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>Sammenh\u00e6ng med kliniske data<\/strong>: De cellul\u00e6re kort blev derefter integreret med patienternes kliniske data. Man fandt ud af, at visse cellul\u00e6re sammens\u00e6tninger er forbundet med d\u00e5rligere patientresultater.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>Validering og afpr\u00f8vning<\/strong>: For at underbygge disse resultater blev der udviklet en sekund\u00e6r model til at forudsige patienternes prognose baseret p\u00e5 andre diagnostiske billeder. Denne model bekr\u00e6ftede de f\u00f8rste resultater og viste sammenh\u00e6nge mellem cellul\u00e6r arkitektur og patienternes overlevelsesrate.<\/span><\/li>\n<\/ol>\n<p>AI fremskynder i h\u00f8j grad datadrevne tilgange til sundhedspleje og underst\u00f8tter <a href=\"https:\/\/dailyai.com\/da\/2023\/06\/ezra-receives-fda-clearance-for-ai-powered-mri-scanner\/\">MRI-scanning,<\/a> <a href=\"https:\/\/dailyai.com\/da\/2023\/06\/ezra-receives-fda-clearance-for-ai-powered-mri-scanner\/\">Diagnostik af \u00f8jensygdomme<\/a>og sofistikeret <a href=\"https:\/\/dailyai.com\/da\/2023\/08\/ai-mind-reading-medical-breakthrough-or-step-towards-dystopia\/\">hjerne-computer-gr\u00e6nseflader<\/a>for blot at n\u00e6vne nogle f\u00e5 af dens utallige anvendelsesmuligheder.<\/p>","protected":false},"excerpt":{"rendered":"<p>Forskere fra Stanford Medicine har udviklet en AI-model, der er designet til at forbedre diagnosticeringen og behandlingen af glioblastom, en s\u00e6rlig aggressiv form for hjernekr\u00e6ft.  Glioblastom giver unikke udfordringer for l\u00e6ger p\u00e5 grund af den meget varierende cellul\u00e6re sammens\u00e6tning fra patient til patient. Olivier Gevaert, lektor i biomedicinsk informatik og datavidenskab, fremh\u00e6vede kompleksiteten i behandlingen af glioblastom og sagde: \"P\u00e5 grund af denne sygdoms heterogenitet har forskerne ikke fundet gode m\u00e5der at tackle den p\u00e5.\" AI-modellen har til form\u00e5l at afhj\u00e6lpe dette problem ved at analysere farvede billeder af glioblastomv\u00e6v for at vurdere dets karakteristika, herunder tumorens aggressivitet og genetik.<\/p>","protected":false},"author":2,"featured_media":4780,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[203,274,204,105,101],"class_list":["post-4779","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-biotech","tag-cancer","tag-healthcare","tag-machine-learning","tag-medtech"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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