{"id":2384,"date":"2023-07-07T20:16:06","date_gmt":"2023-07-07T20:16:06","guid":{"rendered":"https:\/\/dailyai.com\/?p=2384"},"modified":"2023-07-07T21:05:18","modified_gmt":"2023-07-07T21:05:18","slug":"ai-accelerates-discovery-of-anti-aging-drugs-in-new-study","status":"publish","type":"post","link":"https:\/\/dailyai.com\/da\/2023\/07\/ai-accelerates-discovery-of-anti-aging-drugs-in-new-study\/","title":{"rendered":"AI fremskynder opdagelsen af anti-aging-medicin i nyt studie"},"content":{"rendered":"

Et internationalt team af forskere fra University of Edinburgh og det spanske nationale forskningsr\u00e5d IBBTEC-CSIC brugte kunstig intelligens til at fremskynde opdagelsen af anti-aging-medicin.\u00a0<\/b><\/p>\n

Deres <\/span>unders\u00f8gelse<\/span><\/a> identificeret 3 potentielle senolytiske l\u00e6gemidler, der kan bremse aldring og forebygge aldersrelaterede sygdomme. Disse l\u00e6gemidler fungerer ved at eliminere senescente celler, ofte kaldet 'zombieceller'. S\u00e5danne celler forbliver metabolisk aktive, men er ude af stand til at formere sig.<\/span><\/p>\n

At stoppe cellereplikationen fungerer som en forsvarsmekanisme for at forhindre spredning af celleskader, men det er ikke helt ligetil.\u00a0<\/span><\/p>\n

Denne beskyttelsesforanstaltning er prim\u00e6rt designet til at forhindre spredning af celler, der har lidt DNA-skade - for eksempel celler, der er blevet skadet af uds\u00e6ttelse for sollys. Ved at standse replikationen af disse beskadigede celler sikrer kroppen, at skaden ikke spreder sig til flere celler.<\/span><\/p>\n

Men disse celler, der er holdt op med at dele sig, kendt som senescente celler, kan potentielt for\u00e5rsage skade. N\u00e5r de g\u00e5r ind i senescensfasen, begynder de at frigive proteiner, der er kendt for at for\u00e5rsage inflammation.\u00a0<\/span><\/p>\n

Det kan p\u00e5virke sunde naboceller og potentielt skabe et inflammatorisk milj\u00f8.\u00a0<\/span>Over tid kan denne ophobning af inflammation bidrage til forskellige helbredskomplikationer.\u00a0<\/span><\/p>\n

For eksempel er inflammation forbundet med mange sygdomme, herunder neurologiske og degenerative sygdomme, type 2-diabetes, lungefibrose, slidgigt og kr\u00e6ft.\u00a0<\/span><\/p>\n

Selv om oph\u00f8r af cellereplikation er afg\u00f8rende for at forhindre spredning af DNA-skader, kan den inflammatoriske reaktion, der er forbundet med senescente celler, f\u00f8re til andre sundhedsproblemer, hvis den ikke h\u00e5ndteres korrekt.<\/span><\/p>\n

Og det er her, senolytiske l\u00e6gemidler kan hj\u00e6lpe.\u00a0<\/span><\/p>\n

AI's rolle<\/span><\/h2>\n

Tidligere forskning p\u00e5 laboratoriemus viste, at senolytiske l\u00e6gemidler forbedrer dette inflammatoriske scenarie ved at eliminere aldrende celler og sk\u00e5ne de sunde.\u00a0<\/span><\/p>\n

Der findes ca. 80 kendte senolytika, men kun en kombination af to, dasatinib og quercetin, er blevet testet p\u00e5 mennesker.\u00a0<\/span><\/p>\n

Opdagelse af l\u00e6gemidler er us\u00e6dvanligt dyrt og tager normalt 10 til 20 \u00e5r - det er en betydelig flaskehals i l\u00e6gemiddeludviklings-pipelinen. I denne unders\u00f8gelse brugte forskerne maskinl\u00e6ring (ML) til at fremskynde opdagelsen af nye senolytiske l\u00e6gemidler.\u00a0<\/span><\/p>\n

De tr\u00e6nede AI-modeller p\u00e5 eksisterende senolytika og ikke-senolytika, s\u00e5 AI'en kunne skelne mellem dem og forudsige sandsynligheden for, at ukendte molekyler er senolytika.<\/span><\/p>\n

Ud af 4.340 evaluerede molekyler markerede AI'en 21 med stor sandsynlighed for at v\u00e6re senolytiske inden for 5 minutter.\u00a0<\/span><\/p>\n

En af unders\u00f8gelsens forfattere, Dr. Vanessa Smer-Barreto, <\/span>fortalte The Conversation<\/span><\/a> at hvis de blev testet traditionelt i et laboratorium, ville det koste 50.000 pund bare at k\u00f8be stofferne, eksklusive udgifter til udstyr og ops\u00e6tning.<\/span><\/p>\n

Efter in vitro-test p\u00e5 raske og senescente celler eliminerede 3 af de 21 molekyler, periplocin, oleandrin og Linkedin, effektivt senescente celler, mens de sk\u00e5nede normale celler.\u00a0<\/span><\/p>\n

I yderligere tests udkonkurrerede oleandrin, en forbindelse, der findes i oleanderplanten, de mest kendte senolytika af sin slags.<\/span><\/p>\n

Holdet tester nu de tre senolytiske kandidater p\u00e5 humant lungev\u00e6v, og resultaterne forventes at foreligge om ca. to \u00e5r.<\/span><\/p>\n

I l\u00f8bet af de sidste par m\u00e5neder har AI <\/span>identificerede potentielle antibiotika<\/span><\/a> effektiv til at dr\u00e6be resistente bakterier, og et Hong Kong-baseret biotekfirma har f\u00e5et godkendelse til at p\u00e5begynde kliniske fors\u00f8g med en <\/span>AI-opdaget l\u00e6gemiddel<\/span><\/a>.\u00a0<\/span><\/p>\n

AI's evne til at udf\u00f8re komplekse analyser af molekyler fremskynder i h\u00f8j grad den farmaceutiske udviklingspipeline og \u00e5bner nye muligheder for at tackle almindelige og sv\u00e6rt behandlelige tilstande og sygdomme. <\/span><\/p>","protected":false},"excerpt":{"rendered":"

Et internationalt team af forskere fra University of Edinburgh og det spanske nationale forskningsr\u00e5d IBBTEC-CSIC brugte kunstig intelligens til at fremskynde opdagelsen af l\u00e6gemidler mod aldring. Deres unders\u00f8gelse identificerede 3 potentielle senolytiske l\u00e6gemidler, der kan bremse aldring og forebygge aldersrelaterede sygdomme. Disse l\u00e6gemidler fungerer ved at eliminere senescente celler, ofte kaldet 'zombieceller'. S\u00e5danne celler forbliver metabolisk aktive, men er ude af stand til at reproducere sig selv. At stoppe cellereplikationen fungerer som en forsvarsmekanisme for at forhindre spredning af celleskader, men det er ikke helt ligetil. Denne beskyttelsesforanstaltning er prim\u00e6rt designet til at forhindre spredning af celler, der har lidt DNA-skade.<\/p>","protected":false},"author":2,"featured_media":2385,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[203,204,105,101],"class_list":["post-2384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-biotech","tag-healthcare","tag-machine-learning","tag-medtech"],"yoast_head":"\nAI accelerates discovery of anti-aging drugs in new study | DailyAI<\/title>\n<meta name=\"description\" content=\"An international team of researchers from the University of Edinburgh and the Spanish National Research Council IBBTEC-CSIC employed AI to accelerate the discovery of anti-aging drugs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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