{"id":2282,"date":"2023-07-04T08:09:00","date_gmt":"2023-07-04T08:09:00","guid":{"rendered":"https:\/\/dailyai.com\/?p=2282"},"modified":"2023-07-05T08:09:37","modified_gmt":"2023-07-05T08:09:37","slug":"first-ai-generated-drug-given-go-ahead-for-human-trials","status":"publish","type":"post","link":"https:\/\/dailyai.com\/da\/2023\/07\/first-ai-generated-drug-given-go-ahead-for-human-trials\/","title":{"rendered":"F\u00f8rste AI-genererede l\u00e6gemiddel f\u00e5r gr\u00f8nt lys til fors\u00f8g p\u00e5 mennesker"},"content":{"rendered":"

Insilico Medicine har f\u00e5et godkendelse til fors\u00f8g p\u00e5 mennesker med deres helt AI-genererede l\u00e6gemiddel.<\/strong><\/p>\n

L\u00e6gemidlet er udviklet som en potentiel behandling af idiopatisk lungefibrose (IPF), som er en degenerativ sygdom, der for\u00e5rsager ardannelse og fortykkelse af lungev\u00e6vet. IPF rammer omkring 100.000 mennesker alene i USA. Det nye l\u00e6gemiddel, kaldet INS018_055, vil blive afpr\u00f8vet i 12 uger i Kina, og der er planlagt udvidede fors\u00f8g i Kina og USA.<\/span><\/p>\n

Insilico<\/span><\/a> er en Hong Kong-baseret biotekvirksomhed, der bruger AI til at udvikle ny medicin og til forskning i anti-aging. Anvendelsen af AI i deres forskning har gjort det muligt at udvikle nye l\u00e6gemidler meget hurtigere.<\/span><\/p>\n

\"AI giver os mulighed for at analysere enorme m\u00e6ngder data og finde forbindelser, som menneskelige forskere m\u00e5ske overser, og derefter 'forestille' os helt nye molekyler, der kan omdannes til l\u00e6gemidler,\" siger Alex Zhavoronkov, grundl\u00e6gger og CEO af Insilico Medicine.<\/span><\/p>\n

Virksomheden bruger AI i hvert trin af sin strategi for l\u00e6gemiddeludvikling. De bruger f\u00f8rst deres AI-drevne v\u00e6rkt\u00f8j, kaldet PandaOmics, til at identificere et \"m\u00e5l\" eller en biologisk \u00e5rsag, der er forbundet med en bestemt sygdom. M\u00e5let kan f.eks. v\u00e6re et gen eller protein, der ikke fungerer korrekt.<\/span><\/p>\n

N\u00e5r de har identificeret et m\u00e5l, bruger de deres anden AI-platform, Chemistry42, til at designe et molekyle, der afhj\u00e6lper problemet ved at blokere m\u00e5let uden at skade patienten.<\/span><\/p>\n

I dette tilf\u00e6lde henviser \"55\" i l\u00e6gemiddelnavnet til det 55. molekyle, der blev designet og viste sig at v\u00e6re lovende.\u00a0<\/span><\/p>\n

De fase II-fors\u00f8g, der er blevet godkendt, har til form\u00e5l at se, om l\u00e6gemidlet giver en signifikant respons hos de f\u00f8rste deltagere. Hvis det lykkes, vil det g\u00e5 videre til fase III-fors\u00f8g for at bekr\u00e6fte sikkerhed og effektivitet, f\u00f8r FDA-godkendelse kan gives.<\/span><\/p>\n

Insilico Medicine har en r\u00e6kke interessante AI-l\u00e6gemiddeludviklinger i st\u00f8beskeen. FDA har for nylig godkendt den f\u00f8rste IND-ans\u00f8gning (Investigational New Drug) for deres kr\u00e6ftmedicin, der er rettet mod solide tumorer. Fase I-fors\u00f8g er planlagt til juli 2023 i USA og Kina.<\/span><\/p>\n

N\u00e5r vi h\u00f8rer om generativ AI, t\u00e6nker vi normalt p\u00e5 billeder, sange eller tekst, der bliver genereret. Men Insilico bruger generativ AI til at identificere de m\u00e5l, der for\u00e5rsager en sygdom, og derefter designe molekyler, der henvender sig direkte til disse m\u00e5l.<\/span><\/p>\n

Hvis du spurgte ChatGPT, hvilke proteiner der kunne m\u00e5lrettes til behandling af en bestemt type brystkr\u00e6ft, kunne den identificere dem, fordi den har adgang til offentliggjort medicinsk forskning. Insilico har sin egen LLM kaldet ChatPandaGPT, der giver forskere mulighed for at bruge naturlige sprogforesp\u00f8rgsler til at gennemg\u00e5 en specialiseret vidensbase med store m\u00e6ngder kliniske data.<\/span><\/p>\n

Brug af <\/span>AI i medicin<\/span><\/a> hj\u00e6lper virksomheder som Insilico med at forkorte processen med at opdage l\u00e6gemidler dramatisk. Deres <\/span>forskningspipeline<\/span><\/a> har et sp\u00e6ndende udvalg af potentielle behandlinger for forskellige former for kr\u00e6ft samt et COVID-19-l\u00e6gemiddel, der ogs\u00e5 er i fase I-fors\u00f8g.<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Insilico Medicine har f\u00e5et godkendelse til fors\u00f8g p\u00e5 mennesker med deres helt AI-genererede l\u00e6gemiddel. L\u00e6gemidlet er udviklet som en potentiel behandling af idiopatisk lungefibrose (IPF), som er en degenerativ sygdom, der for\u00e5rsager ardannelse og fortykkelse af lungev\u00e6vet. IPF rammer omkring 100.000 mennesker alene i USA. Det nye l\u00e6gemiddel, kaldet INS018_055, vil blive afpr\u00f8vet i 12 uger i Kina, og der er planlagt udvidede fors\u00f8g i Kina og USA. Insilico er en Hong Kong-baseret biotekvirksomhed, som bruger kunstig intelligens til at udvikle nye l\u00e6gemidler og til forskning i anti-aging. Anvendelsen af AI i deres<\/p>","protected":false},"author":6,"featured_media":2283,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[150,107,101],"class_list":["post-2282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-ai-benefits","tag-generative-ai","tag-medtech"],"yoast_head":"\nFirst AI-generated drug given go-ahead for human trials | DailyAI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dailyai.com\/da\/2023\/07\/first-ai-generated-drug-given-go-ahead-for-human-trials\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First AI-generated drug given go-ahead for human trials | DailyAI\" \/>\n<meta property=\"og:description\" content=\"Insilico Medicine has been given approval for human trials of their completely AI-generated drug. The drug has been designed as a potential treatment for idiopathic pulmonary fibrosis (IPF) which is a degenerative disease that causes scarring and thickening of the lung tissues. IPF affects around 100,000 people in the US alone. The new drug, called INS018_055, will be trialed for 12 weeks in China with expanded trials planned for China and the US. Insilico is a Hong Kong based biotech company that uses AI to develop new medicines as well as in anti-aging research. 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