{"id":13108,"date":"2024-06-26T10:57:03","date_gmt":"2024-06-26T10:57:03","guid":{"rendered":"https:\/\/dailyai.com\/?p=13108"},"modified":"2024-06-26T10:57:03","modified_gmt":"2024-06-26T10:57:03","slug":"evolutionaryscales-esm3-a-generative-model-for-biology","status":"publish","type":"post","link":"https:\/\/dailyai.com\/da\/2024\/06\/evolutionaryscales-esm3-a-generative-model-for-biology\/","title":{"rendered":"EvolutionaryScale's ESM3: en generativ model til biologi"},"content":{"rendered":"<p><strong>AI-startup'en EvolutionaryScale har udgivet ESM3, en generativ LLM med 98B parametre til \"programmering af biologi\".<\/strong><\/p>\n<p>Virksomheden fokuserer p\u00e5 proteomik, studiet af interaktioner, funktion, sammens\u00e6tning og strukturer af proteiner og deres cellul\u00e6re aktiviteter.<\/p>\n<p>Mens multimodale modeller som GPT-4 kan generere tekst eller billeder, er ESM3 et AI-v\u00e6rkt\u00f8j til at lave prototyper og skabe <a href=\"https:\/\/dailyai.com\/da\/2024\/05\/alphafold-3-deepmind-evolves-its-ai-protein-folding-project\/\">nye proteiner<\/a>.<\/p>\n<p>N\u00e5r et ribosom skaber et protein, bruger det mRNA, som b\u00e6rer koden til at lave et specifikt protein.<\/p>\n<p>Alle levende organismer deler den samme genetiske kode p\u00e5 tv\u00e6rs af de samme 20 aminosyrer. Hvis man kunne l\u00e6se og forst\u00e5 den kode, kunne man programmere ribosomet til at lave et protein efter behov.<\/p>\n<p>EvolutionaryScale siger, at ESM3 \"forst\u00e5r alle disse biologiske data, overs\u00e6tter dem og taler dem flydende, s\u00e5 de kan bruges som et generativt v\u00e6rkt\u00f8j.\"<\/p>\n<p>I stedet for en omhyggelig og dyr proces med fors\u00f8g og fejl i et laboratorium kan ESM3 forudsige et proteins form og funktion i en simulering.<\/p>\n<blockquote class=\"twitter-tweet\">\n<p dir=\"ltr\" lang=\"en\">Vi har tr\u00e6net ESM3, og vi er glade for at kunne introducere EvolutionaryScale.<\/p>\n<p>ESM3 er en generativ sprogmodel til programmering af biologi. I eksperimenter fandt vi ud af, at ESM3 kan simulere 500 millioner \u00e5rs evolution for at generere nye fluorescerende proteiner.<\/p>\n<p>L\u00e6s mere om det: <a href=\"https:\/\/t.co\/iAC3lkj0iV\">https:\/\/t.co\/iAC3lkj0iV<\/a> <a href=\"https:\/\/t.co\/AhWtC4vxlF\">pic.twitter.com\/AhWtC4vxlF<\/a><\/p>\n<p>- Alex Rives (@alexrives) <a href=\"https:\/\/twitter.com\/alexrives\/status\/1805559211394277697?ref_src=twsrc%5Etfw\">25. juni 2024<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p>ESM3 er tr\u00e6net p\u00e5 tv\u00e6rs af milliarder af proteiner, der findes i naturen. En af de st\u00f8rste udfordringer ved at skabe modellen var at tokenisere den tredimensionelle proteinstruktur og dens funktioner.<\/p>\n<p>Det kr\u00e6vede, at man udviklede en m\u00e5de at skrive alle tredimensionelle strukturer og funktioner som en sekvens af bogstaver ved hj\u00e6lp af diskrete alfabeter.<\/p>\n<p>N\u00e5r ESM3 er blevet tr\u00e6net p\u00e5 milliarder af proteiner, taler den naturens sprog flydende og kan r\u00e6sonnere over proteinernes sekvens, struktur og funktion.<\/p>\n<p>Som en demonstration af ESM3's evner brugte EvolutionaryScale det til at generere et nyt gr\u00f8nt fluorescerende protein (GFP). GFP'er er ansvarlige for den smukke fluorescens, vi ser i nogle livsformer som vandm\u00e6nd eller koraller.<\/p>\n<figure id=\"attachment_13110\" aria-describedby=\"caption-attachment-13110\" style=\"width: 1080px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13110 size-full\" src=\"https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP.png\" alt=\"\" width=\"1080\" height=\"1080\" srcset=\"https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP.png 1080w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-300x300.png 300w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-1024x1024.png 1024w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-150x150.png 150w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-768x768.png 768w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-12x12.png 12w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-60x60.png 60w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-480x480.png 480w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-24x24.png 24w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-48x48.png 48w, https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/esmGFP-96x96.png 96w\" sizes=\"auto, (max-width: 1080px) 100vw, 1080px\" \/><figcaption id=\"caption-attachment-13110\" class=\"wp-caption-text\">En gengivelse af esmGFP, et nyt gr\u00f8nt fluorescerende protein genereret af ESM3. Kilde: EvolutionaryScale<\/figcaption><\/figure>\n<p>GFP'er er utroligt sj\u00e6ldne i naturen. Virksomheden vurderer, at det nye protein, som de kalder esmGFP, \"svarer til over 500 millioner \u00e5rs naturlig evolution udf\u00f8rt af en evolution\u00e6r simulator.\"<\/p>\n<p>EvolutionaryScale g\u00f8r ESM3-modellen \u00e5bent tilg\u00e6ngelig og h\u00e5ber, at den vil \"give forskere mulighed for at udforske gr\u00e6nserne for proteindesign og syntetisk biologi og opfinde nye l\u00f8sninger p\u00e5 nogle af de vigtigste problemer, som vores verden st\u00e5r over for.\"<\/p>\n<p>Den dobbelte anvendelse og open source-karakteren af et v\u00e6rkt\u00f8j som ESM3 rejser potentielle risici, som virksomheden siger, at den vil afb\u00f8de med sit Responsible Development Framework.<\/p>\n<p>At bruge AI til at programmere biologi p\u00e5 en forudsigelig m\u00e5de kan f\u00f8re til proteiner, der indfanger kulstof, forbruger genstridige forurenende stoffer som plastik eller ny medicin.<\/p>\n<p>AI-fremskridt i v\u00e6rkt\u00f8jer som ESM3, AlphaFold og CRISPR kan snart f\u00f8re til udryddelse af sygdomme og milj\u00f8problemer, som har udfordret forskere i \u00e5rtier.<\/p>","protected":false},"excerpt":{"rendered":"<p>AI-startup'en EvolutionaryScale har udgivet ESM3, en generativ LLM med 98B parametre til \"programmering af biologi\". Virksomheden fokuserer p\u00e5 proteomik, studiet af interaktioner, funktion, sammens\u00e6tning og strukturer af proteiner og deres cellul\u00e6re aktiviteter. Mens multimodale modeller som GPT-4 kan generere tekst eller billeder, er ESM3 et AI-v\u00e6rkt\u00f8j til at lave prototyper og skabe nye proteiner. N\u00e5r et ribosom skaber et protein, bruger det mRNA, som b\u00e6rer koden til at lave et specifikt protein. Alle levende organismer deler den samme genetiske kode p\u00e5 tv\u00e6rs af de samme 20 aminosyrer. Hvis man kunne l\u00e6se og forst\u00e5 den kode, kunne man programmere ribosomet.<\/p>","protected":false},"author":6,"featured_media":13111,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[150,107],"class_list":["post-13108","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry","tag-ai-benefits","tag-generative-ai"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>EvolutionaryScale\u2019s ESM3: a generative model for biology | DailyAI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dailyai.com\/da\/2024\/06\/evolutionaryscales-esm3-a-generative-model-for-biology\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EvolutionaryScale\u2019s ESM3: a generative model for biology | DailyAI\" \/>\n<meta property=\"og:description\" content=\"AI startup EvolutionaryScale has released ESM3, a 98B-parameter generative LLM for &#8220;programming biology&#8221;. The company is focused on proteomics, the study of the interactions, function, composition, and structures of proteins and their cellular activities. While multimodal models like GPT-4 can generate text or images, ESM3 is an AI tool for prototyping and creating new proteins. When a ribosome creates a protein, it uses mRNA which carries the code for making a specific protein. Every living organism shares the same genetic code across the same 20 amino acids. If you could read and understand that code you could program the ribosome\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dailyai.com\/da\/2024\/06\/evolutionaryscales-esm3-a-generative-model-for-biology\/\" \/>\n<meta property=\"og:site_name\" content=\"DailyAI\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-26T10:57:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dailyai.com\/wp-content\/uploads\/2024\/06\/AI-protein-design.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1792\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Eugene van der Watt\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@DailyAIOfficial\" \/>\n<meta name=\"twitter:site\" content=\"@DailyAIOfficial\" \/>\n<meta name=\"twitter:label1\" content=\"Skrevet af\" \/>\n\t<meta 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